Neuro-SEM Unveiled: Mapping Brain, Behavior, and Decision-Making
PDF

Keywords

meta-analytic structural equation modeling (MASEM)
latent variable analysis
mediation and moderation effects
psychometric modeling
neuro structural equation modeling (neuro-SEM)

How to Cite

NG KOK WAH, J. . (2025). Neuro-SEM Unveiled: Mapping Brain, Behavior, and Decision-Making. Global Health Synapse, 2(1), 15-31. https://doi.org/10.63456/ghs-2-1-12

Abstract

The study aims to explore the intricate relationships between brain activity, behavioral processes, and decision-making using structural equation modeling (SEM) techniques. While existing research has advanced our understanding of these domains, gaps remain in synthesizing neurocognitive and behavioral factors in a unified framework. The primary objective of the study is to examine the neural mechanisms underlying decision-making and behavior, focusing on how brain function influences both cognitive and emotional decision processes. By integrating insights from neuroimaging, behavioral analysis, and decision theory, the study presents a novel approach to mapping these interconnected systems through SEM. The findings indicate significant associations between brain structures and behavioral outcomes, such as emotion regulation, impulsivity, and decision-making biases. Moreover, the study highlights contrasting evidence regarding the role of brain areas in cognitive flexibility and decision consistency, pointing to unresolved questions in neurocognitive models of decision-making. Key trends identified include the increasing use of neuroimaging and SEM to bridge the gap between neurological and behavioral research, alongside emerging methodologies to assess the dynamic interaction between cognitive processes and decision outcomes. The study's contributions lie in offering a comprehensive SEM-based framework for understanding brain-behavior interactions, providing a holistic model that accommodates both cognitive and emotional components in decision-making. However, the study also faces limitations, such as the reliance on cross-sectional data and potential biases in model selection. Future research should explore longitudinal studies to examine the evolution of brain-behavior dynamics over time and investigate the neurobiological basis of maladaptive decision-making, particularly in clinical populations. This work holds significant implications for improving our understanding of the neurocognitive underpinnings of behavior and decision-making, with applications ranging from mental health interventions to consumer behavior and policy design.

PDF

References

[1] Allen, K. J., Elliott, M. V., Ronold, E. H., Rajgopal, N. A., Hammar, Å., & Johnson, S. L. (2025). The Memory and Affective Flexibility Task: a new behavioral tool to assess neurocognitive processes implicated in emotion-related impulsivity and internalizing symptoms. Frontiers in Psychiatry, 16, 1456691.

[2] Arab, R., & Forghani, M. (2025). Using the ANFIS and FDEA approach in modeling and evaluating the role of new product development on the organization's performance by involving resilience. Journal of Applied Research on Industrial Engineering, 12(1), 54-71.

[3] Bagherzadeh, R., Gharibi, T., Nik, A. S., & Vahedparast, H. (2025). Relationship Between Intimate Partner Violence and Quality of Life Among Women with Chronic Diseases: Mediating and Moderating Role of Sense of Coherence. Violence Against Women, 10778012241309363.

[4] Burstein, O., Sabag, M., Kurtzman, L., & Geva, R. (2025). The role of focused attention in learning from early childhood to late adolescence: Implications of neonatal brainstem compromise following preterm birth. Child Development.

[5] Chaudhary, M. K., Mahato, S., & Adhikari, M. (2025). The effectiveness of online learning in the emerging academic environment: A Structural Equation Modelling (SEM) approach. FIIB Business Review, 14(1), 103-113.

[6] Cheng, Q., Zhao, L., & Li, W. (2025). The Internal Structure and Influence Mechanism of Double Qualified-Teachers’ Quality and Competence. Education and Urban Society, 57(1), 13-39.

[7] Cordero, G., Paredes-Paredes, J. R., Perea, M., Sebastian-Galles, N., & Díaz, B. (2025). Voice processing ability predicts second-language phoneme learning in early bilingual adults. Bilingualism: Language and Cognition, 1-18.

[8] Daneshvar, S., Bytamar, J. M., Zeraatpisheh, Z., Zand, S., Sahraian, A., & Jobson, L. (2025). Adverse childhood experiences and suicidal ideation in patients with major depressive disorder: investigating the mediating role of emotional reactivity and probabilistic and reinforcement learning. BMC psychology, 13(1), 11.

[9] da Silva Pereira-Rufino, L., Gobbo, D. R., Conte, R., de Sino, R. M., de Oliveira, N. N., Fidalgo, T. M., ... & Céspedes, I. C. (2025). Reduced gray matter volume in limbic and cortical areas is associated with anxiety and depression in alcohol use disorder patients. Psychiatry Research: Neuroimaging, 111946.

[10] da Silva Pereira-Rufino, L., Gobbo, D. R., Conte, R., de Sino Romano, R. M., Vissoto, T. C. S., da Conceição, M. C., ... & Céspedes, I. C. (2025). Multiple Dimensions Approach in Polysubstance Use: An ESEM Analysis Based on the RDoC Framework. Psychiatry Research: Neuroimaging, 111959.

[11] Demetrakos, C., NAKATO, I., ROMERO-PEREZ, S., Kyutoku, Y., & Dan, I. (2025). Psychological factors that influence behavioral intentions towards bottled green tea in the Japanese market. International Journal of Affective Engineering, 24(1), 103-114.

[12] Ershadi Manesh, S., & Mokalaee, M. (2025). Structural model of inhibition and behavioral activation system and cognitive control and flexibility with adolescent depression with the mediating role of rumination. Journal of Psychological Science, 24(145), 1-21.

[13] Han, X., Li, Y., Wang, J., Liu, X., Zhang, Y., Dong, Q., ... & Qiu, C. (2025). Associations between lifelong cognitive reserve, Alzheimer's disease-related plasma biomarkers, and cognitive function in dementia-free older adults: A population-based study. Journal of Alzheimer’s Disease, 13872877241306448.

[14] Kock, N. (2025). Methods showcase using PLSF-SEM in business communication research. International Journal of Business Communication, 62(1), 187-205.

[15] Mirbagheri, S. M., Rafiei Atani, A., Parsanejad, M. R., & Jafari, R. (2025). Structural equation modeling of collective decision-making's impact on group cohesion. International Journal of Human Capital in Urban Management, 10(1), 39-56.

[16] Nazaripour, M., & Zakizadeh, B. (2025). Neurotransmitters and the Behavior of Individual Investors: Exploratory and Confirmatory Factor Analysis. Iranian Journal of Finance, 9(1), 162-186.

[17] Pala, D., Xie, Y., Xu, J., & Shen, L. (2025). Modeling the impact of socioeconomic disparity, biological markers and environmental exposures on phenotypic age using mediation analysis and structural equation models. International Journal of Medical Informatics, 193, 105661.

[18] Rashidifar, M., & Karami, M. (2025). Early Maladaptive Schemas, Body Dysmorphic Disorder (BDD) and the Mediation Role of Rumination and Emotional Cognitive Regulation: A Focus on Cosmetics Surgery Applicants. In Proceedings of the International Conference on Research in Psychology (Vol. 2, No. 1, pp. 29-43).

[19] Saffari, M., Huang, C. H., Huang, P. C., Chang, Y. H., Chen, J. S., Poon, W. C., ... & Lin, C. Y. (2025). Mediating roles of weight stigma and physical activity avoidance in the associations between severity of gaming disorder and levels of physical activity among young adults. Journal of Behavioral Addictions.

[20] Swami, V., Voracek, M., Furnham, A., Horne, G., Longhurst, P., & Tran, U. S. (2025). Is nature exposure in autistic adults associated with more positive body image?. Body Image, 52, 101854.

[21] Thakur, M., & Sharma, S. (2025). Exploring Tourist Attitudes and Satisfaction in Religious Tourism Through Neuro Marketing in Mandi District's Himachal Pradesh. In Neuromarketing's Role in Sustainable Finance (pp. 309-328). IGI Global.

[22] Vattipally, V. N., Ran, K. R., Das, O., Aude, C. A., Giwa, G. A., Rincon-Torroella, J., ... & Bettegowda, C. (2025). Latent Variable Analysis of Demographic and Clinical Drivers of Care Intensity Before Palliative Care Consultation Among Older Adult Patients with Traumatic Brain Injury. Neurocritical Care, 1-9.

[23] Wu, C., Chau, P. H., & Choi, E. P. H. (2025). Exploring Social-Ecological Pathways from Sexual Identity to Sleep Among Chinese Women: Structural Equation Modeling Analysis. JMIR Public Health and Surveillance, 11(1), e53549.

[24] Yu, H., Li, X., Yu, X., Fusheng, L., Li, L., & Yang, Y. Impact of Physical Exercise on Life Satisfaction of Chinese Senior College Students: The Mediating Role of Self-Efficacy and Psychological Resilience. Frontiers in Psychology, 16, 1515101.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2025 DR. JACK NG KOK WAH (Author)